In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver
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Whether those acute effects translate to sustained synaptogenic benefits over weeks or months remains an open questionhuman trial data on Dihexa is limited to a handful of small-scale studies, none of which directly compared oral vs sublingual pharmacokinetics in humans
Evidence Relying on anecdotal evidence can be misleading
